ESR position 8 – University of Oslo

Comparison of methods and assays for SCLC biomarkers using MIP based protein or peptide capture phases

Host Institute

Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo

Host Country


Start date

During the period March 1st – September 1st 2017

The candidate will be employed at the Department of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo  and will be enrolled in the department PhD program under the supervision by Prof. Léon Reubsaet and ass. prof. Trine Grønhaug Halvorsen

Project description

Small Cell Lung Cancer (SCLC) is an aggressive form of lung cancer (1 out of 5 lung cancers) with a short survival after diagnosis (few months). Since it is sensitive for treatment, early diagnosis or proper monitoring is of high interest. Most effort is put in the design of the sample preparation and the possibility to determine multiple SCLC markers simultaneously (like ProGRP and NSE) at ultra low concentrations as well as the possibility to differentiate between existing isovariants which might allow a more robust and personalized diagnostic profile in the future.

During the project the candidate will work with implementing Molecular Imprinted Polymers in the sample preparation step of and bottom-up LC-MS analysis of validated ultra low abundant biomarkers for SCLC.

The project will include secondments to University of Strathclyde, Glasgow (UK) – molecular imprinting and sensor technology. Biotage, Lund (Sweden) – method validation; University of Umeå, Umeå (Sweden) – monolithic separation materials; University of Southern Denmark, Odense (DK), Proteome Sciences, London (UK) – bioanalytical techniques, biomarker assays, modification specific proteomics

The secondments will allow you to work with and oversee the design and synthesis of the materials and to gain insight into academic and industrial work environments.

The candidate will be enrolled in the 3 year PhD-program at the Faculty of Mathematics and Natural Science and will be expected to complete a PhD including completion of local academic and network wide training requirements. The research topic is “Analyical Chemistry” and the Faculty examines Doctors of Philosophy. 

Group description

The Bioanalytical chemistry group at the University of Oslo carries out research in the field of targeted protein analysis using LC-MS/MS. The main focus is on the sample preparation and clean-up step to allow determination of extreme low amounts of biomarkers in complex biological samples like plasma and blood. The group is linked to the prioritized research initiative DIATECH.

Institute description

The University of Oslo offers more than 800 courses in English at all levels, around 40 Master’s degree programmes taught entirely in English and several PhD programmes. UiO focuses on research-based education and attracts highly qualified students from all over the country. As a classical university with a broad range of academic disciplines, UiO has top research communities in most areas. Moreover, UiO currently has 8 National Centres of Excellence and a strategic focus on interdisciplinary research in the field of energy and life sciences in particular. UiO has about 28 000 students and is situated in Oslo, the largest city in Norway

Ideal candidate

The successful candidate will have a masters’ degree (or equivalent) in chemistry preferably analytical chemistry with knowledge of polymer chemistry. Experimental laboratory experience is required and candidates with experience directly related to the research topic of the position outlined above will be given preference.

Working conditions and benefits

The candidate will become an employee of the Department of Pharmaceutical Chemistry and receive a competitive monthly gross salary in accordance with the EC Marie Sklodowska-Curie rules. The contract period will last for 3 years.


For more information on this position, contact the hiring party: Prof. Leon Reubsaet

Phone: +47-22856613

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